His career was marked by a willingness to compromise, often shifting between opposition and government roles. This included joining President Daniel arap Moi's government as energy minister and later leading the campaign against President Mwai Kibaki's proposed constitution, which helped consolidate the Orange Democratic Movement (ODM).

Following the violence after the disputed 2007 election, Odinga became Prime Minister in a power-sharing agreement. He later played a significant role in the 2010 constitutional referendum, which expanded rights and strengthened checks on executive power.

The Supreme Court's annulment of the 2017 election highlighted the judiciary's role in checking executive power, though underlying electoral trust issues persisted. Odinga's subsequent "handshake" with President Uhuru Kenyatta led to the Building Bridges Initiative, which aimed to address governance but ultimately failed in court.

His final years saw him lead protests against the cost of living and taxation, though younger generations began challenging established political hierarchies. A late-career pact with President William Ruto aimed to ease political tensions and advance reforms, but it also created divisions within Odinga's party.